Endocrine Abstracts

Accurate assessment of the hypothalamic–pituitary–adrenal (HPA) axis is important for the appropriate management of patients with pituitary tumours after transsphenoidal surgery. The aim of our study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing postoperative HPA axis function. We performed a retrospective analysis of 68 patients (male:female=36:32, age 59.5 years, range 21–77) treated by transsphenoidal surg...

Functional interplay between different classes of receptors has emerged as a notable factor of cellular response in health and disease. One of the most prominent examples of cross-talk involves the regulation of glucose metabolism, a major regulatory function under the influence of both insulin receptor (IR) and β2-adrenergic receptor (β2-AR) representing the receptor tyrosine kinases (RTKs) and the seven transmembrane receptors (7TMRs) respecti...

Primary hyperparathyroidism (PHPT) is nowadays usually diagnosed as an asymptomatic disease but it might be related with advanced end-organ damage. Parathyroid incidentaloma (PI) is the term describing enlarged parathyroid nodules that are unexpectedly discovered on surgery or by imaging performed for nonparathyroid disorders. The recognition of PI might uncover a clinically significant PHPT with the potential for surgical cure. We retrospectively reviewed patients’ reco...

Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover.Methods: Twenty-eight patients with active acromegaly (14 women; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission....

Intrathyroidally located parathyroid carcinoma is extremely rare cause of primary hyperparathyroidism. Multifocal papillary and follicular thyroid carcinomas are rather common.We report a case of 40-year old man presenting with substantial weight loss, anemia and multiple osteolytic lesions of both tibias. Peak serum calcium level was 5.0 mmol/l, parathyroid hormone (PTH) level was 989 pg/ml. Left thyroid lobe was firm and enlarged. Routine percutaneous ...

A 74-year-old female patient was admitted to Department of Neurology due to bilateral ptosis and diplopia she suddenly felt 3 weeks prior to admission. She also complained of weakness, dizziness and swallow disability. Her medical history revealed hypertension and minor depressive disorder. Body mass index was 32 kg/m2. Electrocardiogram, chest X-ray and complete laboratory findings were normal, except elevated TSH, so levothyroxin was included in therapy. She had p...

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and lipid levels in patients with PHPT. In 21 patients with PHPT (age: 56.24±8.69 years, BMI 25.2±3.81 kg/m2) lipid levels (TC, HDL, LDL, TG, Lp(a)) and insulin sensitivity were determinated before and 4 months after surgical treatment. Insulin sensitivity was evalu...

Hyperprolactinaemia is the most common disturbance in the pituitary gland function. Different physiological and patological conditions could influnce prolactin (PRL) secretion. Prolactin secreting tumors (micro and macroprolactinomas) are rare in children and adolescents (estimated incidence is 1 per milion). Functional diversity of prolactin action is responsable for different initial clinical expression of hyperprolactinaemia.We investigated causes of ...

Patients with primary hyperparathyroidism (PHPT) are insulin resistant. The effect of PHPT on lipid levels and low-grade inflammation leves is unknown. The aim of our study was to estimate the cardiovascular risk profile in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years; PTH 180.83±104.15 ng/l, calcium 2.97±0.19 mmol/l) insulin sensitivity (measured using euglycemic hyperinsulinemic clamp - M value), lipids (total choleste...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years) insulin sensitivity was estimated using euglycemic hyperinsulinemic clamp (M value) before and 3 months after su...